Whole brain radiotherapy: Consequences for personalized medicine
نویسندگان
چکیده
منابع مشابه
Whole brain radiotherapy for brain metastasis
Whole brain radiotherapy (WBRT) is a mainstay of treatment in patients with both identifiable brain metastases and prophylaxis for microscopic disease. The use of WBRT has decreased somewhat in recent years due to both advances in radiation technology, allowing for a more localized delivery of radiation, and growing concerns regarding the late toxicity profile associated with WBRT. This has pro...
متن کاملBrain metastases: fractionated whole-brain radiotherapy.
Brain metastases are the most common malignant adult intracranial tumors, occurring in approximately 10-30% of cancer patients, and generally lead to a poor prognosis. The incidence has been steadily rising, likely due to longer survival from newer systemic therapies and increased utilization of magnetic resonance imaging. Historically, whole-brain radiotherapy has been a standard of care for t...
متن کاملWhole brain radiotherapy with radiosensitizer for brain metastases
PURPOSE To study the efficacy of whole brain radiotherapy (WBRT) with radiosensitizer in comparison with WBRT alone for patients with brain metastases in terms of overall survival, disease progression, response to treatment and adverse effects of treatment. METHODS A meta-analysis of randomized controlled trials (RCT) was performed in order to compare WBRT with radiosensitizer for brain metas...
متن کاملRe-irradiation for metastatic brain tumors with whole-brain radiotherapy.
OBJECTIVE To determine whether second whole-brain irradiation is beneficial for patients previously treated with whole-brain irradiation. METHODS A retrospective analysis was done for 31 patients with brain metastases who had undergone re-irradiation. Initial whole-brain irradiation was performed with 30 Gy/10 fractions for 87% of these patients. Whole-brain re-irradiation was performed with ...
متن کاملConcurrent whole brain radiotherapy and bortezomib for brain metastasis
BACKGROUND Survival of patients with brain metastasis particularly from historically more radio-resistant malignancies remains dismal. A phase I study of concurrent bortezomib and whole brain radiotherapy was conducted to determine the tolerance and safety of this approach in patients with previously untreated brain metastasis. METHODS A phase I dose escalation study evaluated the safety of b...
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ژورنال
عنوان ژورنال: Reports of Practical Oncology & Radiotherapy
سال: 2013
ISSN: 1507-1367
DOI: 10.1016/j.rpor.2013.03.002